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KMID : 0377520150400030067
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Chung-Ang Journal of Medicine
2015 Volume.40 No. 3 p.67 ~ p.70
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A Case of Transient Sixth Nerve Palsy after Combination Therapy of Capecitabine Plus Bevacizumab in Colon Cancer Patient
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Kwon Min-Suk
Huh Jung
Park Song-Ee
Choi Chang-Won
Hong Jung-Yong
Moon Nam-Ju
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Abstract
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We report a transient sixth nerve palsy case after administration of capecitabine and bevacizumab. A 37-year-old woman with advanced colon cancer developed diplopia due to a sixth nerve palsy, 7 weeks after receiving capecitabine and bevacizumab. Brain imaging with MRI did not show a space occupying lesion or vascular lesion that could explain her sixth nerve palsy. After stopping all chemotherapeutic drugs for 4 weeks, the diplopia resolved without special therapy. Considering her previous history of long-term exposure to 5-fluorouracil as the metabolite of capecitabine, the bevacizumab was causative drug, associated with sixth nerve palsy. This is the first reported case of bevacizumab induced sixth nerve palsy in colon cancer.
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KEYWORD
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Bevacizumab, Sixth nerve palsy
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